Biology Department Faculty

Thomas Chiles

Professor and Deluca Chair of Biology

Vice Provost for Research & Academic Planning

Research

The laboratory is interested in understanding how extrinsic signals influence B lymphocyte growth and survival. We are currently focused on investigating the regulation and function of D-type cyclins in splenic B-2 and peritoneal B-1a cells in response to B-cell antigen receptor engagement. Effort is also directed toward investigating the bioenergetics underlying B-2 lymphocyte survival, specifically identifying signaling and nutrient energy metabolic pathways linked to IL-4 receptors. Specifically, we are using 13C-glucose/13C-glutamine together with 2D-NMR and mass spectrometry to elucidate metabolic pathways that support lymphocyte survival. We are also designing novel carbon nanotube structures in order to efficiently introduce macromolecules (e.g., siRNAs, genes, proteins) into primary B lymphocytes. Additional interests are directed toward developing nanosensors for multiplex detection of disease biomarkers (e.g., cancer and infectious diseases).