Understanding complex biological systems demand novel tools allowing the investigator to probe and manipulate its specific components. One major focus of our group is the development and application of methods enabling site-specific labeling of any chosen protein in a living cell with useful biochemical and biophysical probes to investigate its function in its native environment. Another focus of our group is developing proteins with novel functions by rational and directed evolution. We are also interested in augmenting the functional potential of proteins by introducing new chemical moieties within the canonical protein-scaffold. Research in our group combines elements from a diverse set of disciplines spanning synthetic chemistry, biochemistry, molecular biology and cell biology.
