[see below for information on how to participate]
Anorexia nervosa is a serious disorder. It is associated with life-threatening medical complications, significant chronicity, and less than optimal outcomes including high mortality rates. A research team, headed up by Dr. Barbara Wolfe is examining the neurobiology of anorexia nervosa. Investigators are currently following-up on previous studies suggesting that decreased serotonin function in the brain may play a role in accompanying symptoms (e.g., depression), tendency for relapse, and limited effectiveness of medications that target the serotonin system in this population. Brain serotonin is dependent upon nutrients from food, more specifically, the amino acid tryptophan. The team is interested in understanding the possible contribution of intermittent and /or persistent dieting to the availability of tryptophan and brain levels of serotonin. Results will help clarify the usefulness of new strategies for improving the function of these systems. To hear more about the study, please contact Michael McKenery at 617 552-2758 or at mmckener@bidmc.harvard.edu.
Interested in Participating?
The study is currently enrolling women age 18-45 who are either currently diagnosed with, or recovered from, symptoms of Anorexia Nervosa and also healthy controls. Volunteers must be in stable medical condition, and not taking medications (with the exception of oral contraceptives). For this study of behavioral ratings and blood hormone levels. Eligible participants will receive up to $550 for a total of 4 outpatient visits and two overnight stays at the Clinical Research Unit at Beth Israel Deaconess Medical Center.