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Professors Byers, Hoveyda, Kelly, Liu, Morken, Snapper, Wasa, & Zhang
Amir H. Hoveyda

Joseph T. and Patricia Vanderslice Millennium Professor of Chemistry

Contact Information:

Ph.D., Yale University, 1986

American Cancer Society Postdoctoral Fellow, Harvard University, 1986–87; 1988–90

Selected Honors & Awards:

Yamada-Koga Prize, 2010

American Chemical Society Award for Creative Work in Organic Synthesis, 2014

Eni Award, 2014

We discover, design and develop new catalysts for chemical synthesis that are easily prepared, are stable to air and moisture and can be recycled. We introduce efficient new chiral catalysts that can be used to synthesize important enantiomerically pure compounds for the preparation of biologically and medicinally active agents. Our focus is on transformations that are truly important (such as conjugate additions and olefin metathesis), but cannot be catalyzed efficiently by existing methods. We are interested in complex molecule total synthesis (testing our catalysts), study of reaction mechanism (how do our catalysts work?) and new approaches to catalyst discovery (combinatorial chemistry).

Representative Key Publications:

Z-Selective Catalytic Olefin Cross-Metathesis for Natural Product Synthesis,” S. J. Meek, R. V. O’Brien, J. Llaveria, R. R. Schrock, A. H. Hoveyda, Nature 2011, 471, 461.

“Simple Organic Molecules as Catalysts for Enantioselective Synthesis of Amines and Alcohols,” D. L. Silverio, S. Torker, T. Palyugina, E. M. Vieira, M. L. Snapper, F. Haeffner, A. H. Hoveyda, Nature 2013, 494, 216.

“Multifunctional Organoboron Compounds for Scalable Natural Product Synthesis,” F. Meng, K. P. McGrath, A. H. Hoveyda, Nature 2014, 513, 367.

“High-value alcohols and higher-oxidation-state compounds by catalytic Z-selective cross-metathesis,” M. J. Koh, R. K. M. Khan, S. Torker, M. Yu, M. S. Mikus, A. H. Hoveyda, Nature 2015, 517, 181.