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Two Marth lab’s papers appeared in February 2008 issue of Nature Methods journal

BC Biology News

Nature Methods
February 2008, Vol.5 No 2.
See papers online >


Two papers of BC biologists from Prof. Marth's lab have recently appeared in the February 2008 issue of Nature Methods. One of the papers, called "Pyrobayes: an improved base caller for SNP discovery in pyrosequences," is written by Gábor T. Marth, his post-doc, Chip Stewart, and two graduate students, Aaron Quinlan and Mike Strömberg. Pyrobayes is a new base-calling program for pyrosequencing reads from the 454 Life Sciences sequencing machines. The program permits accurate single-nucleotide polymorphism (SNP) calling in resequencing applications. The advantage of the new Pyrobayes program is that it produces more confident base calls than the native base calling program. 


Another Marth lab’s paper, called "Whole-genome sequencing and variant discovery in C. elegans," was a collaboration between the BC biologists and their colleagues from the Washington University School of Medicine. They developed a new improved  approach to determine the regions of the genome to which short reads could be uniquely mapped. The study was conducted using  the Solexa Sequence Analyzer  reads from C. elegans strain CB4858. In this paper, the authors demonstrate the utility of massively parallel short read sequencing for whole genome resequencing and for accurate discovery of genome-wide polymorphisms.