Representative Publications

Crane, M.T. and Chiles, T.C. 2011. Why the Liberal Arts Need the Sciences (and Vice Versa). Commentary. The Chronicle of Higher Education. Nov. 13.

Strelko, C.L., Lu, W., Dufort, F.J., Seyfried, T.N., Chiles, T.C., Rabinowitz, J.D., and Roberts, M.F. 2011. Itaconic acid, a polymer building block, is a novel mammalian metabolite induced during macrophage activation. J. Am. Chem. Soc. 133:16386-16389.

Jammallo, L., Eidell, K., Davis, P.H., Dufort, F.J., Cronin, C., Thirugnanam, S., Chiles,  T.C., Roos, D.S., and Gubbels, M.J. 2010. An insertional trap for conditional gene expression in Toxoplasma gondii: Identification of TAF250 as an essential gene. Mol. Biochem. Parasitol. 175:133-143.

Gumina, M.R., Xu, C., Chiles, T.C. 2010. Cyclin D3 is dispensable for human diffuse large B-cell lymphoma survival and growth: Evidence for redundancy with cyclin E. Cell Cycle 9(4): 820-828. Epub 2010, Mar. 2 (link to PubMed abstract).

Yu, Y., Cimeno, A., Lan, Y.C., Rybczynski, J., Wang, D.Z., Paudel, T., Ren, Z.F, Wagner, D.J., Qiu, M. Q., Chiles, T.C., and Cai, D. 2009. Assembly of multi-functional nanocomponents on periodic nanotube array for biosensors. Micro & Nano Letters 4: 27-33 (link to PubMed abstract).

Cai, D., Blair, D., Dufort, F.J., Gumina, M.R., Huang, Z., Hong, G., Wagner, D., Canahan, D., Kempa, K., Ren, Z.F., and Chiles, T. C. 2008. Interaction between carbon nanotubes and mammalian cells: characterization by flow cytometry and application. Nanotechnology 19 (34): 1-10 (link to PubMed abstract).

Wang, Y.K., Chen, W., Blair, D., Pu, M., Xu, Y., Miller, S.J., Redfield, A.G., Chiles, T.C., Roberts, M.F. 2008. Insights into the structural specificity of the cytotoxicity of 3-deoxyphosphatidylinositols. Journal of the American Chemical Society 130(24): 7746-55. Epub 2008 May 23 (link to PubMed abstract).

Mukherjee, P., Mulrooney, T.J., Marsh, J., Blair, D., Chiles, T.C., Seyfried, T.N. 2008. Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain. Molecular Cancer 7: 37 (link to PubMed abstract).

Mukherjee, P., Faber, A.C., Shelton, L.M., Baek, R.C., Chiles, T.C., Seyfried, T.N. 2008. Thematic review series: sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. Journal of Lipid Research 49(5) : 929-38. Epub 2008 Feb. 20 (link to PubMed abstract).

Cai, D., Yu, Y., Lan, Y., Dufort, F.J., Xiong, G., Paudel, T., Ren, Z., Wagner, D.J., and Chiles, T.C. 2007. Glucose sensors made of novel carbon nanotube-gold nanoparticle composites. Biofactors 30(4): 271-277 (link to PubMed abstract).

Faber, A.C., and Chiles, T.C. 2007. Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas.Cell Cycle 6(23): 2982-9 (link to PubMed abstract).

Dufort, F.J., Bleiman, B., Gumina, M.R., Blair, D.,  Wagner, D.J, Roberts, M.F., Abu-Amer, Y., and T.C. Chiles. 2007. Interleukin-4-mediated protection of primary B lymphocytes from apoptosis through Stat6-dependent up-regulation of glycolytic metabolism. Cutting Edge: Journal of Immunology 179: 4953-4957 (link to PubMed abstract).

Chiles, T.C., Cai, D., Doughty, C.A., Potocky, T.B., Dufort, F.J., Huang, Z., Blair, D., Kempa, K., Ren, Z.F. 2007. Carbon nanotube-mediated delivery of nucleic acids does not result in non-specific activation of B lymphocytes. Nanotechnology 18: 365101.

Chiles, T.C., Mahon, K.P., Potocky, T.B., Blair, D., Roy, M. D., Stewart, K. M., and Kelley, S.O. 2007. Deconvolution of the cellular oxidative stress response with organelle-specific peptide conjugates. Chemistry & Biology 14: 923-30 (link to PubMed abstract).

Guo, B., Blair, D., Chiles, T.C., Lowell, C.A., Rothstein, T.L. 2007. B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn.  Cutting Edge: Journal of Immunology 178: 4726-4730 (link to PubMed abstract).

Faber, A. C., and Chiles, T.C. 2006. Resveratrol induces apoptosis in transformed follicular lymphoma OCI-LY8 cells: evidence for a novel mechanism involving inhibition of BCL6 signaling. International Journal of Oncology  29(6): 1561-6  (link to PubMed abstract).

Faber, A. C., Dufort, F. J., Blair, D., Wagner, D., Roberts, M. F., Chiles, T. C. 2006. Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas. Biochemical Pharmacology 72(10): 1246-56 (link to PubMed abstract).

Mataraza, J. M., Tumang, J. R., Gumina, M. R., Gurdak, S. M., Rothstein, T. L., and Chiles, T. C. 2006. Disruption of cyclin D3 blocks proliferation of normal B-1a cells, but loss of cyclin D3 is compensated by cyclin D2 in cyclin D3-deficient mice. Journal of Immunology 177(2): 787-95 (link to PubMed abstract).

Doughty, C. A., Bleiman, B. F., Wagner, D. J., Dufort, F. J., Mataraza, J. M., Roberts, M. F., and Chiles, T. C. 2006. Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107(11): 4458-65 (link to PubMed abstract).

Cai, D., Mataraza, J. M., Qin, Z. H., Huang, Z., Huang, J., Chiles, T. C., Carnahan, D., Kempa, K., and Ren, Z. 2005. Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing. Nature Methods 2(6): 449-54 (link to PubMed abstract).

Piatelli, M. J., Wardle, C., Blois, J., Doughty, C., Schram, B. R., Rothstein, T. L., and Chiles, T. C. 2004. Phosphatidylinositol 3-kinase-dependent MEK1/2-ERK and NF-B signaling pathways are required for B cell antigen receptor-mediated cyclin D2 induction in mature B lymphocytes. Journal of Immunology 172: 2753-2762 (link to PubMed abstract).

Chiles, T. C. 2004. Regulation and function of cyclin D2 in B-cell subsets. Journal of Immunology 173: 2901-2907 (link to PubMed abstract).

Blois, J. T., Mataraza, J. M., Mecklenbr?uker, I., Tarakhovsky, A., and Chiles, T.C. 2004. B cell receptor-induced cAMP-response element binding protein activation in B lymphocytes requires novel protein kinase C-delta. Journal of Biological Chemistry 279: 30123-30132 (link to PubMed abstract).

Piatelli, M.J., Tanguay, D., Rothstein, T.L., and Chiles, T. C. 2003. Cell cycle control mechanisms in B-1 and B-2 lymphocyte subsets. Immunological Research 27: 31-51 (link to PubMed abstract).

Piatelli, M.J., Doughty, C., and Chiles, T.C. 2002. Role of a hsp90-dependent, Mek-1/ERK signaling module that regulates B cell antigen receptor-induced cyclin D2 transcription. Journal of Biological Chemistry 277: 12144-12150 (link to PubMed abstract).

Tanguay, D.A., Colarusso, T.P., Pavlovic, S., Doughty, C., Rothstein, T.L., and Chiles, T.C. 2001. Differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsets. Cutting Edge: Journal of Immunology 166: 4273-4277 (link to PubMed abstract).

Rothstein, T.L., Fischer, G.M., Tanguay, D.A., Pavlovic, S., Colarusso, T.P., Gerstein, R.M., Clarke, S.H., and Chiles, T.C. 2000. STAT3 activation, chemokine receptor expression, and cyclin-Cdk function in B-1 cells. Current Topics in Microbiology and Immunology 252: 121-130 (link to PubMed abstract).

Swart, J.M., and Chiles, T.C. 2000. Rescue of CH31 B cells from antigen receptor-induced apoptosis by inhibition of p38 MAPK. Biochemical and Biophysical Research Communications 275: 417-421 (link to PubMed abstract).

Swart, J.M., Bergeron, D.M, and Chiles, T.C. 2000. Identification of a membrane Ig-induced p38 mitogen-activated protein kinase module that regulates cAMP response element binding protein phosphorylation and transcriptional activation in CH31 B cell lymphoma. Journal of Immunology 164: 2311-2319 (link to PubMed abstract).

Tanguay, D.A., Colarusso, T.P., Pavlovic, S., Howard, R.G., Bartek, J., Chiles, T.C., and Rothstein, T.L. 1999. Induction of G1-cyclin expression and Cdk activation in phorbol ester- responsive B-1 cells. Journal of Experimental Medicine 189: 1685-1690 (link to PubMed abstract).

Tanguay, D., Pavlovic, S., Piatelli, M.J., Bartek, J., and Chiles, T.C. 1999. B cell antigen receptor-mediated activation of cyclin-dependent retinoblastoma protein kinases and inhibition by co-cross-linking with Fc receptors. Journal of Immunology 163: 3160-3168 (link to PubMed abstract).

Amato, S.F., Swart, J.M., Berg, M., Wanebo, H.J., Metha, S.R., and Chiles, T.C. 1998. Transient stimulation of the JNK/AP-1 pathway and inhibition of ERK-2 activity are early effects of paclitaxel-mediated apoptosis in human  B-lymphoblast. Cancer Research 58: 241-247 (link to PubMed abstract).

Amato, S.F., Nakajima, K., Hirano, T., and Chiles, T.C. 1997. Transcriptional regulation of the junB gene in B lymphocytes: Role of protein kinase A and a membrane immuno-globulin-regulated protein phosphatase. Journal of Immunology 159: 4676-4685 (link to PubMed abstract).

Amato, S.F., Nakajima, K., Hirano, T., and Chiles, T.C. 1996. Transcriptional regulation of the junB promoter in mature B lymphocytes: activation through a CRE-like binding site. Journal of Immunology 157: 146-154 (link to PubMed abstract).

Tanguay, D.A., and Chiles, T.C. 1996. Regulation of the catalytic subunit (p34PSK-J3/cdk4) for the major D-type cyclin in mature B lymphocytes. Journal of Immunology 156: 539-548 (link to PubMed abstract).