RESEARCH
Faculty research topics include:
Thomas
Chiles, Ph.D.
Investigations into the metabolic pathways and signaling transduction underlying
B cell growth responses to antigen challenge. Cell cycle control of peritoneal
B-1a cells, including hyperproliferative responses.
Marc-Jan Gubbels, Ph.D.
Host cell invasion is at the heart of apicomplexan parasite pathogenesis. We
use Toxoplasma gondii as a genetically tractable model to dissect this
process. In addition we are analyzing the internal budding of daughter parasites
during T. gondii cell division. Identification of key players in processes
unique to the biology of Apicomplexa (invasion and division) is the first step
towards development of more effective therapeutic options.
Charles Hoffman, Ph.D.
Investigations into fungal glucose/cAMP signaling using the genetically pliable
fission yeast Schizosaccharomyces pombe. This nutrient sensing
pathway is homologous to those of fungal pathogens that regulate dimorphic growth
and host tissue invasion in response to their nutrient environment.
Junona Moroianu, Ph.D.
Study of the nuclear import pathways of Human Papillomavirus (HPV) proteins and genomes during the viral infection and the transformation process leading to cervical cancer.
Marc
Muskavitch, Ph.D.
Investigations of the development and cell biology of the midgut of the malarial
mosquito, Anopheles gambiae, and of interactions between the midgut and
the malarial parasite. Investigations of the role of the subcellular trafficking
machinery in arboviral infection of the midgut in Aedes aegypti.
William
Petri, Ph.D.
Investigations of the developmental regulation of gene
expression in Drosophila eggshell genes.
