Fields of Interest

Molecular biology of Toxoplasma cell division; signal transduction; fungal biology.

Academic Profile

My research has focused on problems in both basic and applied areas of biomedical research, including signal transduction in fungi, vaccine development for Valley Fever and the development of a high-throughput small molecule screening platform.

My current research focus utilizes a combination of genetics, cell biology, proteomics and biochemistry to identify cell division components in the parasite Toxoplasma gondii and to uncover their roles in daughter cell formation.

Representative Publications

Anderson-White, B.R., Ivey, F.D., Cheng, K., Szatanek, T., Lorestani, A., Beckers, C.J., Ferguson, D.J.P., Sahoo, N. and Gubbels, M.J. 2010. “A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii.” Cellular Microbiology.

Ivey, F.D., Taglia, F.X., Yang, F., Lander, M.M., Kelly, D.A., Hoffman, C.S. 2010. “Activated Alleles of the Schizosaccharomyces pombe gpa2+ Gα Gene Identify Residues Involved in GDP-GTP Exchange.” Eukaryotic Cell. 9(4):626-33.

Alaamery, M.A. Wyman, A.R., Ivey, F.D., Allain, C., Demirbas, D., Wang, L., Ceyhan, O., Hoffman, C.S. 2010. “New classes of PDE7 inhibitors identified by a fission yeast-based HTS.” Journal of Biomolecular Screening 15(4):359-67.

Ivey, F.D., Wang, L., Demirbas, D., Allain, C., Hoffman, C.S. 2008.  Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases. Journal of Biomolecular Screening 13: 62–71.

Kao, R.S., Morreale, E., Wang, L., Ivey, F.D., and Hoffman, C.S. 2006. Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase. Genetics 173: 49–61.

Wang, L., Griffiths Jr., K., Zhang, Y.H., Ivey, F.D., and Hoffman, C.S. 2005. Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling. Genetics 171: 1523–33.

Ivey, F.D., and Hoffman, C.S. 2005. Direct activation of fission yeast adenylate cyclase by the Gpa2 Ga of the glucose signaling pathway. Proceedings of the National Academy of Sciences of the USA 102(17): 6108–13.

Wang, L., Kao, R., Ivey, F.D., and Hoffman, C.S. 2004. Strategies for gene disruptions and plasmid constructions in fission yeast. Methods 33(3): 199–205.

Ivey, F.D., Magee, D.M., Woitaske, M.D., Johnston, S.A., and Cox, R.A. 2003. Identification of a protective antigen of Coccidioides immitis by expression library immunization. Vaccine 21: 4359–4367.

Ivey, F.D., and Hoffman, C.S. 2002. Pseudostructural inhibitors of G protein signaling during development. Developmental Cell (Preview) 3(2): 154–5.

Jiang, C., Magee, D.M., Ivey, F.D., and Cox, R.A. 2002. Role of signal sequence in vaccine-induced protection against experimental coccidioidomycosis. Infection and Immunity 70(7): 3539–45.

Ivey, F.D., Kays, A.M., and Borkovich, K.A. 2002. Shared and independent roles for a Gai protein and adenylyl cyclase in regulating development and stress responses in Neurospora crassa. Eukaryotic Cell 1(4): 634–642.

Ivey, F.D., Yang, Q., and Borkovich, K.A. 1999. Positive regulation of adenylyl cyclase activity by a Gai homologue in Neurospora crassa. Fungal Genetics and Biology 26: 48–61.

Ivey, F.D., Hodge, P.N., Turner, G.E., and Borkovich, K.A. 1996. The Gai homologue gna-1 controls multiple differentiation pathways in Neurospora crassa. Molecular Biology of the Cell 7: 1283–1297.