Thomas Chiles
chairperson, professor of biology
Ph.D., University of Florida, College of Medicine
Tel: (617) 552-0840
E-mail: thomas.chiles@bc.edu
Fields of Interest
We are interested in understanding how extrinsic signals influence B lymphocyte growth and survival. The laboratory is currently focused on investigating the regulation and function of D-type cyclins in splenic B-2 and peritoneal B-1a cells in response to B-cell antigen receptor engagement. Our effort is also directed toward investigating the bioenergetics underlying B-2 lymphocyte survival, specifically identifying signaling and glucose energy metabolic pathways linked to IL-4 receptors. We are designing novel carbon nanotube structures in order to develop technologies to introduce macromolecules into primary B lymphocytes.
Key Representative Publications
Wang, Y.K., Chen, W., Blair, D., Pu, M., Xu, Y., Miller, S.J., Redfield, A.G., Chiles, T.C., Roberts, M.F. 2008. Insights into the structural specificity of the cytotoxicity of 3-deoxyphosphatidylinositols. Journal of the American Chemical Society 130(24): 7746–7755. Epub 2008 May 23.
Faber, A.C. and Chiles, T.C. 2007. Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas. Cell Cycle 6(23): 2982–2989.
Dufort, F.J., Bleiman, B., Gumina, M.R., Blair, D., Wagner, D.J, Roberts, M.F., Abu-Amer, Y., and Chiles, T. C. 2007. Interleukin-4-mediated protection of primary B lymphocytes from apoptosis through Stat6-dependent up-regulation of glycolytic metabolism. Cutting Edge: Journal of Immunology 179: 4953–4957.
Chiles, T.C., Mahon, K.P., Potocky, T.B., Blair, D., Roy, M. D., Stewart, K. M., and Kelley, S.O. 2007. Deconvolution of the cellular oxidative stress response with organelle-specific peptide conjugates. Chemistry & Biology 14(8): 923–930.
Doughty, C. A., Bleiman, B. F., Wagner, D. J., Dufort, F. J., Mataraza, J. M., Roberts, M. F., and Chiles, T. C. 2006. Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107(11): 4458–4465.
Cai, D., Mataraza, J. M., Qin, Z. H., Huang, Z., Huang, J., Chiles, T. C., Carnahan, D., Kempa, K., and Ren, Z. 2005. Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing. Nature Methods 2(6): 449–454.
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