BI 535 Structural Biochemistry of Neurological Diseases (Spring: 3)

Prerequisite: BI 435 or CH 561
The goal of structural biology is to relate molecular form to biological function. Characterizing biological processes in terms of the molecular structures and interactions of their constituents is accomplished using methods including: x-ray crystallography, and fiber and membrane diffraction; NMR spectroscopy; light and electron microscopy, and atomic force microscopy; computation; and modern molecular biology. This course will focus on the nerve myelin sheath. The objective is to thoroughly introduce the student in myelinology. Topics include: (1) Myelin Function, Formation, Biochemistry, Structure; (2) Diseases Involving Myelin; (3) CNS Myelin: PLP-Related Disorders; and (4) PNS Myelin: P0 and PMP22-Related Disorders.
Daniel Kirschner

Last Updated: 03-FEB-12