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A Molecule with Therapeutic Potential for Reducing Tumor Blood Vessels

 

T.Chiles T.Seyfried P.Mukherjee
Biology Prof. and Chairperson Thomas Chiles Biology Prof. Thomas Seyfried Biology Res. Assist. Prof. Purna Mukherjee

 

 The recent collaborative work of Biology Profs. T. Seyfried, T. Chiles, and P. Mukherjee was focused on a molecule that can help solve one of the biggest challenges of the 21st century – cancer therapy.

 

In their work recently published in the Journal of Lipid Research, they investigated the ability of a simple sugar-containing lipid molecule, GM3, to counteract the effects of blood vessel growth factors.  GM3 suppressed the action of these growth factors on the proliferation of human umbilical vein endothelial cells and inhibited their migration.

 

The study shows that GM3 suppresses the growth of blood vessels, which grow around the tumor and feed it. This finding presents compelling evidence that the results of this research can be applied to reduce tumor angiogenesis (a physiological process involving the growth of new blood vessels from pre-existing vessels).